DRUG-RESISTANCE IN ONCOLOGY - FROM CONCEPTS TO APPLICATIONS

被引:10
作者
CAZIN, JL [1 ]
GOSSELIN, P [1 ]
CAPPELAERE, P [1 ]
ROBERT, J [1 ]
DEMAILLE, A [1 ]
机构
[1] FDN BERGONIE,BIOCHIM LAB,F-33076 BORDEAUX,FRANCE
关键词
ONCOPHARMACOLOGY; RESISTANCE TO CHEMOTHERAPY; PGP; GST; TOPOISOMERASES;
D O I
10.1007/BF01209660
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The complex problem of drug resistance is discussed with respect to host toxicity, to tumor characteristics (kinetic resistance, heterogeneity of cell subpopulations, hypoxia, mutation and gene amplification), and to the medication itself (pharmacokinetic and pharmacodynamic resistance: cell membrane, intracellular metabolism, intracellular target). After detailing each type of resistance, the possibilities of fighting against drug resistance are explored (dealing with host toxicity, tumor characteristics and drugs - intensifying therapy, multiple drug therapy, biochemical modulation, particular modalities of drug administration). Finally, perspectives of research and development of new drugs are summarized.
引用
收藏
页码:76 / 86
页数:11
相关论文
共 107 条
[1]  
ALBRECHT AM, 1984, FOLATE ANTAGONISTS T, P317
[2]  
ALT FW, 1978, J BIOL CHEM, V253, P1351
[3]  
ARMAND JP, 1986, THERAPEUTIQUE, P193
[4]   DESIGN OF DNA INTERCALATORS TO OVERCOME TOPOISOMERASE II-MEDIATED MULTIDRUG RESISTANCE [J].
BAGULEY, BC ;
HOLDAWAY, KM ;
FRAY, LM .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (05) :398-402
[5]   PLEIOTROPIC PHENOTYPE OF COLCHICINE-RESISTANT CHO CELLS - CROSS-RESISTANCE AND COLLATERAL SENSITIVITY [J].
BECHHANSEN, NT ;
TILL, JE ;
LING, V .
JOURNAL OF CELLULAR PHYSIOLOGY, 1976, 88 (01) :23-31
[6]  
BECK WT, 1990, B CANCER, V77, P1131
[7]  
BECK WT, 1987, CANCER RES, V47, P5455
[8]  
Benet L., 1990, PHARMACOL BASIS THER, P3
[9]  
BIEDLER J, 1971, SCIENCE, V191, P185
[10]  
BIEDLER JL, 1970, CANCER RES, V30, P1174