NATURAL OCCURRENCE OF 2-5A IN INTERFERON-TREATED EMC VIRUS-INFECTED L-CELLS

被引：246

作者：

WILLIAMS, BRG

GOLGHER, RR

BROWN, RE

GILBERT, CS

KERR, IM

机构：

[1] National Institute for Medical Research, London NW7, Mill Hill

[2] Departmento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte

来源：

NATURE | 1979年 / 282卷 / 5739期

关键词：

D O I：

10.1038/282582a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Until now the inierfer on-mediated 2′-5′ adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth. © 1979 Nature Publishing Group.

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页码：582 / 586

页数：5

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