REASSESSMENT OF BREAKPOINTS IN CHROMOSOME-11P15

被引：10

作者：

HENRY, I

VANHEYNINGEN, V

PUECH, A

SCRABLE, H

AUGEREAU, P

BOEHM, T

RABBITTS, T

MANNENS, M

ROCHEFORT, H

JONES, C

CAVENEE, W

JUNIEN, C

机构：

[1] INSERM,U73,CHATEAU DE LONGCHAMP,BOIS DE BOULOGNE,F-75016 PARIS,FRANCE

[2] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

[3] LUDWIG INST CANC RES,MONTREAL,PQ,CANADA

[4] INSERM,U148,F-34100 MONTPELLIER,FRANCE

[5] MRC,MOLEC BIOL LAB,CAMBRIDGE,ENGLAND

[6] UNIV AMSTERDAM,ACAD MED CTR,INST HUMAN GENET,1105 AZ AMSTERDAM,NETHERLANDS

[7] ELEANOR ROOSEVELT INST CANC RES,DENVER,CO

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 62卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1159/000133444

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specific tumor-associated rearrangements involving the regions 11p13 and 11p15 have been extensively documented. However, cytogenetic definition of the breakpoints occurring at the boundaries of these two regions was not precise enough to correlate with the molecular data. Using probes corresponding to the genes coding for MYOD1, CTSD, LDHA, and RBTN1 and to the anonymous sequence D11S776, we have reassessed the breakpoints of three hybrids (J1.10, BID7, and NYX3.1) and confirmed the localization or more precisely mapped these four genes and the anonymous DNA marker on different subregions of 11pter-->p13, including the smallest region of 11p15.5 duplicated in a patient with Beckwith-Wiedemann syndrome.

引用

页码：52 / 53

页数：2

共 19 条

[1] CLONING AND SEQUENCING OF THE 52K CATHEPSIN-D COMPLEMENTARY DEOXYRIBONUCLEIC-ACID OF MCF7 BREAST-CANCER CELLS AND MAPPING ON CHROMOSOME-11 [J].