CYTOGENETIC EFFECTS OF PERMETHRIN IN CULTURED HUMAN-LYMPHOCYTES

被引：30

作者：

BARRUECO, C ^{[1
]}

HERRERA, A ^{[1
]}

CABALLO, C ^{[1
]}

DELAPENA, E ^{[1
]}

机构：

[1] CSIC, CTR CIENCIAS MEDIOAMBIENTALES, E-28006 MADRID, SPAIN

来源：

MUTAGENESIS | 1992年 / 7卷 / 06期

关键词：

D O I：

10.1093/mutage/7.6.433

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The pyrethroid insecticide permethrin was tested for its ability to induce sister chromatid exchanges (SCE), micronuclei (MN) and structural chromosome aberrations (CA) in cultured human peripheral blood lymphocytes. Permethrin was tested in the range of 5-500 mug/ml in the absence and in the presence of a rat liver activation system (S9 mix). Small elevations in the SCE frequencies were found and even though statistically significant may have no biological meaning, the more so since there was no dose-effect relationship. Permethrin induced both MN and CA when it was evaluated in the absence of a metabolic activation system. Nevertheless, it cannot be said that S9 mix suppressed the activity in itself. The effect of permethrin seemed to be time of exposure dependent. Permethrin could be characterized as a S-phase independent agent with greater potential for inducing chromosomal damage than sister chromatid exchanges.

引用

页码：433 / 437

页数：5

共 26 条

[1]

BRADBURY SP, 1989, REV ENVIRON CONTAM T, V108, P133

[2] SISTER CHROMATID EXCHANGE AND GENE MUTATION [J].

CARRANO, AV ;

THOMPSON, LH .

CYTOGENETICS AND CELL GENETICS, 1982, 33 (1-2) :57-61

[3] PYRETHRUM FLOWERS AND PYRETHROID INSECTICIDES [J].

CASIDA, JE .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1980, 34 (FEB) :189-202

[4] PROPERTIES AND APPLICATIONS OF PYRETHROIDS [J].

ELLIOTT, M .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1976, 14 (APR) :3-13

[5] PHOTOSTABLE PYRETHROID [J].

ELLIOTT, M ;

FARNHAM, AW ;

JANES, NF ;

NEEDHAM, PH ;

PULMAN, DA ;

STEVENSON, JH .

NATURE, 1973, 246 (5429) :169-170

[6] FUTURE OF PYRETHROIDS IN INSECT CONTROL [J].

ELLIOTT, M ;

JANES, NF ;

POTTER, C .

ANNUAL REVIEW OF ENTOMOLOGY, 1978, 23 :443-469

[7] MUTAGENIC POTENTIAL OF PERMETHRIN IN THE DROSOPHILA-MELANOGASTER (DIPTERA, DROSOPHILIDAE) SEX-LINKED RECESSIVE LETHAL TEST [J].

GUPTA, RK ;

MEHR, ZA ;

KORTE, DW ;

RUTLEDGE, LC .

JOURNAL OF ECONOMIC ENTOMOLOGY, 1990, 83 (03) :721-724

[8] MUTAGENIC ACTIVITY IN SYNTHETIC PYRETHROIDS IN SALMONELLA-TYPHIMURIUM [J].

HERRERA, A ;

LABORDA, E .

MUTAGENESIS, 1988, 3 (06) :509-514

[9] TABLES FOR DETERMINING STATISTICAL SIGNIFICANCE OF MUTATION FREQUENCIES [J].

KASTENBAUM, MA ;

BOWMAN, KO .

MUTATION RESEARCH, 1970, 9 (05) :527-+

[10] CELL-KINETICS AND SISTER-CHROMATID-EXCHANGE FREQUENCY IN HUMAN-LYMPHOCYTES [J].

LAMBERTI, L ;

PONZETTO, PB ;

ARDITO, G .

MUTATION RESEARCH, 1983, 120 (2-3) :193-199

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