EXPRESSION OF ANGIOTENSIN-II AT(2) RECEPTORS IN THE RAT SKIN DURING EXPERIMENTAL WOUND-HEALING

被引：160

作者：

VISWANATHAN, M

SAAVEDRA, JM

机构：

[1] Rm. 2D-45

来源：

PEPTIDES | 1992年 / 13卷 / 04期

关键词：

ANGIOTENSIN-II; AT(1) RECEPTORS; AT(2) RECEPTORS; SKIN; WOUND HEALING;

D O I：

10.1016/0196-9781(92)90187-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We localized and characterized angiotensin II AT1 and AT2 receptors in the skin of 2-week-old rats during experimental wound healing. Both AT1 and AT2 were present in the skin. Three days after wounding, the expression of angiotensin II receptors was significantly enhanced in the dermis as well as in a localized band within the superficial dermis of the skin surrounding the wound. The major proportion of this increase was due to angiotensin II AT2 receptors. Our results suggest a physiological role for AT2 receptors in the process of tissue repair.

引用

页码：783 / 786

页数：4

共 17 条

[1] NOMENCLATURE FOR ANGIOTENSIN RECEPTORS - A REPORT OF THE NOMENCLATURE-COMMITTEE OF THE COUNCIL-FOR-HIGH-BLOOD-PRESSURE-RESEARCH [J].