PROTEIN-BINDING AND IVERMECTIN ESTIMATIONS IN PATIENTS WITH ONCHOCERCIASIS

被引:40
作者
OKONKWO, PO
OGBUOKIRI, JE
OFOEGBU, E
KLOTZ, U
机构
[1] FISCHER BOSCH INST CLIN PHARMACOL, STUTTGART, GERMANY
[2] UNIV NIGERIA, COLL MED, DEPT PHARMACOL & THERAPEUT, ENUGU, NIGERIA
[3] UNIV NIGERIA, COLL MED, DEPT MED, ENUGU, NIGERIA
关键词
D O I
10.1038/clpt.1993.46
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We measured ivermectin in plasma, urine, and saliva of nine patients with onchocerciasis. The aim was to establish pharmacokinetic parameters and to assess the most facile medium for use in monitoring compliance. Binding of ivermectin to plasma proteins in vitro was also investigated. The mean (+/-SEM) plasma values for the nine subjects were as follows: weight, 66.3 +/- 2.8 kg; dose, 11.11 +/- 0.4 mg; half-life, 56.50 +/- 7.01 hours; clearance, 142.5 +/- 22.6 L/kg; volume of distribution, 9.91 +/- 2.67 L/kg; area under the plasma concentration-time curve, 1545.3 +/- 190.5 ng/ml . hr; time to reach maximum concentration, 4.7 +/- 0.5 hours; and maximum concentration, 38.2 +/- 5.8 ng/ml. Ivermectin was not detected in the urine of any of the nine subjects. Low levels were found in saliva. Blood specimens remain the only reliable biologic fluid for assessment of compliance after ivermectin oral administration. Ivermectin binds specifically to human serum albumin.
引用
收藏
页码:426 / 430
页数:5
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