A MILD AND SELECTIVE C-3 REDUCTIVE ALKYLATION OF INDOLES

被引：41

作者：

APPLETON, JE ^{[1
]}

DACK, KN ^{[1
]}

GREEN, AD ^{[1
]}

STEELE, J ^{[1
]}

机构：

[1] PFIZER LTD,DEPT DISCOVERY CHEM,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(00)60337-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of triethylsilane and trifluoroacetic acid, the reaction between indoles and aldehydes in dichloromethane at 0-degrees-C, results in good yields of C-3 reductively alkylated products. The transformation is most effective for the preparation of 3-(arylmethyl)indoles 6 from aromatic aldehydes.

引用

页码：1529 / 1532

页数：4

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