EXPRESSION OF DIFFERENT MITOGEN-REGULATED PROTEIN/PROLIFERIN MESSENGER-RNAS IN EHRLICH CARCINOMA-CELLS

被引：7

作者：

GILTORREGROSA, B ^{[1
]}

URDIALES, JL ^{[1
]}

LOZANO, J ^{[1
]}

MATES, JM ^{[1
]}

SANCHEZJIMENEZ, F ^{[1
]}

机构：

[1] UNIV MALAGA,FAC CIENCIAS,BIOQUIM & BIOL MOLEC LAB,E-29071 MALAGA,SPAIN

来源：

FEBS LETTERS | 1994年 / 349卷 / 03期

关键词：

PROLIFERIN; MITOGEN-REGULATED PROTEIN; EHRLICH CARCINOMA;

D O I：

10.1016/0014-5793(94)00698-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Results from in vivo and from serum-free primary cultures of Ehrlich cells suggest that the expression of mitogen-regulated protein/proliferin (MRP/PLF) mRNAs is not essential for proliferation of this murine tumor. Two sizes for MRP/PRL-related open reading frames (ORFs) have been detected by reverse transcription/PCR amplification. They are almost identical to that reported for PLF-1; but 20% of the amplified cDNA included a shorter ORF, which lacks the entire sequence corresponding to that of the exon 3 of the mrp/plf genes. Ehrlich carcinoma may represent a good model to study regulation of expression and physiological roles of MRP/PLFs in vivo.

引用

页码：343 / 348

页数：6

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