ASYMMETRIC-SYNTHESIS OF 1,1-DISUBSTITUTED TETRALINS AND DIHYDRONAPHTHALENES BY DIASTEREOSELECTIVE ADDITION OF LITHIOSILANES TO CHIRAL NAPHTHALENES

被引：18

作者：

HULME, AN ^{[1
]}

MEYERS, AI ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 05期

关键词：

D O I：

10.1021/jo00084a007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly diastereoselective additions of lithiosilanes to chiral naphthalenes can be performed in ether/THF. Trapping of the resulting azaenolate, followed by protodesilylation, allows access to 1,1-disubstituted tetralins or dihydronaphthalenes in good yields and high enantiomeric excess.

引用

页码：952 / 953

页数：2

共 7 条

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