IDENTIFICATION OF 2 URINARY INDOLE MELANOGENS BY THIN-LAYER CHROMATOGRAPHY

被引:8
作者
BADINAND, A
PASQUIER, J
VALLON, JJ
GUILLUY, R
MILON, H
机构
[1] Laboratoire Central de Chimie Biologique, Hôpital E. Herriot, Lyon, et Laboratoire de Chimie Analytique Pharmaceutique, Faculté mixte de Médecine et de Pharmacie, 8, Avenue Rockfeller
关键词
D O I
10.1016/0009-8981(69)90193-4
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
An indole melanogen has been identified in melanotic urine, by thin-layer bidimensional chromatography on cellulose. According to data given by Duchon and coll., this compound was presumed to be a mixture of 5-hydroxy-6-methoxy indole 2-carboxylic and 5-methoxy-6-hydroxy indole 2-carboxylic acid. This indole compound has been isolated and identified by Chromatographic, spectrophotometric and spectrofluorimetric methods, and with mass spectrometry. Thin-layer chromatography on cellulose after enzymatic hydrolysis of urines is proposed for simultaneous detection of phenol and indole melanogens. © 1969.
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页码:357 / &
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