PHARMACOKINETICS OF E-5-(2-BROMOVINYL)-2'-DEOXYURIDINE IN MICE

被引：28

作者：

DECLERCQ, E ^{[1
]}

DESCAMPS, J ^{[1
]}

DESOMER, P ^{[1
]}

BARR, PJ ^{[1
]}

JONES, AS ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, DEPT CHEM, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 16卷 / 02期

关键词：

D O I：

10.1128/AAC.16.2.234

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pharmacokinetics of the newly developed anti-herpes agent, E-5-(2-bromovinyl)-2'-deoxyuridine, was compared with that of the standard anti-herpes drug 5-iodo-2'-deoxyuridine. Both compounds were administered to mice at 100 mg/kg by either the intraperitoneal, subcutaneous, or oral route. The active blood drug levels achieved by E-5-(2-bromovinyl)-2'-deoxyuridine were considerably higher than those attained by 5-iodo-2'-deoxyuridine (serum peak concentrations: 40 to 100 and 4 to 10 μg/ml, respectively). Active blood drug levels could still be found 320 min after oral administration of E-5-(2-bromovinyl)-2'-deoxyuridine.

引用

页码：234 / 236

页数：3

共 4 条

[1] Bauer DJ, 1977, SPECIFIC TREATMENT V
[2] DECLERCQ E, 1979, P NATL ACAD SCI USA, V76, P2947, DOI 10.1073/pnas.76.6.2947
[3] HERPESVIRUS-HOMINIS INFECTION IN NEWBORN MICE .1. EXPERIMENTAL MODEL AND THERAPY WITH IODODEOXYURIDINE
KERN, ER
OVERALL, JC
GLASGOW, LA
[J]. JOURNAL OF INFECTIOUS DISEASES, 1973, 128 (03) : 290 - 299
[4] 9-(2-HYDROXYETHOXYMETHYL)GUANINE ACTIVITY AGAINST VIRUSES OF HERPES GROUP
SCHAEFFER, HJ
BEAUCHAMP, L
MIRANDA, PD
ELION, GB
BAUER, DJ
COLLINS, P
[J]. NATURE, 1978, 272 (5654) : 583 - 585

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