SYNTHESIS OF ARABINOFURANOSYL DERIVATIVES OF 3-DEAZAGUANINE

被引：17

作者：

POONIAN, MS ^{[1
]}

MCCOMAS, WW ^{[1
]}

KRAMER, MJ ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,DEPT CHEMOTHERAPY,NUTLEY,NJ 07110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1021/jm00194a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of four arabinofuranosyl derivatives of the antitumor agent 3-deazaguanine is described. By the use of 13C and 1H nuclear magnetic resonance spectroscopy, the structures of these nucleosides were established to be a and β pairs of N-7 and N-9 arabinosides of 3-deazaguanine. In contrast to 3-deazaguanine and its ribosyl derivative, the nucleosides described in this paper were found to be inactive against Sarcoma 180 in mice at 100 mg/kg. © 1979, American Chemical Society. All rights reserved.

引用

页码：958 / 962

页数：5

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