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ACTIVITY OF PENTAMIDINE AND PENTAMIDINE ANALOGS AGAINST TOXOPLASMA-GONDII IN CELL-CULTURES

被引：46
作者：
LINDSAY, DS
BLAGBURN, BL
HALL, JE
TIDWELL, RR
机构：
[1] UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,SCH MED,DEPT PATHOL,CHAPEL HILL,NC 27599
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 09期
关键词：
D O I：
10.1128/AAC.35.9.1914
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The capabilities of pentamidine and nine pentamidine analogs to inhibit the development of Toxoplasma gondii were examined in vitro. Treatment of infected cultures with pentamidine and five of its analogs caused a significant (P < 0.05) reduction in the numbers of tachyzoites produced. Analogs of pentamidine may be useful agents in the treatment of toxoplasmosis.
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页码：1914 / 1916
页数：3
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