DIRECTED METALATION STUDIES ON 2-(2-HETEROARYL)IMIDAZOLINES - SYNTHESIS OF SOME 2,3-DISUBSTITUTED THIOPHENES AND FURANS

被引：9

作者：

CHADWICK, DJ ^{[1
]}

ENNIS, DS ^{[1
]}

机构：

[1] UNIV LIVERPOOL, ROBERT ROBINSON LABS, LIVERPOOL L69 3BX, ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 47期

关键词：

IMIDAZOLINE; DIRECTED METALATION; THIOPHENES; FURANS;

D O I：

10.1016/S0040-4020(01)80726-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the synthesis of 2-(2-heteroaryl)imidazolines (1a-c) has been developed and subsequent metallation studies have shown the imidazoline group to be a strong director of ortho-metallation. The synthetic utility of lithio intermediates (5) and (7) has been shown by reaction with a series of electrophiles.

引用

页码：9901 / 9914

页数：14

共 12 条

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[4]

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[6]

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[7]

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