EPSTEIN-BARR VIRUS-INDUCED GENES - 1ST LYMPHOCYTE-SPECIFIC G-PROTEIN-COUPLED PEPTIDE RECEPTORS

被引:297
作者
BIRKENBACH, M
JOSEFSEN, K
YALAMANCHILI, R
LENOIR, G
KIEFF, E
机构
[1] HARVARD UNIV,DEPT MED,VIROL PROGRAM,75 FRANCIS ST,BOSTON,MA 02115
[2] KOMMUNE HOSP COPENHAGEN,BARTHOLIN INST,DK-1399 COPENHAGEN K,DENMARK
[3] HARVARD UNIV,DEPT MICROBIOL & MOLEC GENET,VIROL PROGRAM,BOSTON,MA 02115
[4] INT AGCY RES CANC,F-69372 LYON,FRANCE
关键词
D O I
10.1128/JVI.67.4.2209-2220.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Since Epstein-Barr virus (EBV) infection of Burkitt's lymphoma (BL) cells in vitro reproduces many of the activation effects of EBV infection of primary B lymphocytes, mRNAs induced in BL cells have been cloned and identified by subtractive hybridization. Nine genes encode RNAs which are 4- to > 100-fold more abundant after EBV infection. Two of these, the genes for CD21 and vimentin, were previously known to be induced by EBV infection. Five others, the genes for cathepsin H, annexin VI (p68), serglycin proteoglycan core protein, CD44, and the myristylated alanine-rich protein kinase C substrate (MARCKS), are genes which were not previously known to be induced by EBV infection. Two novel genes, EBV-induced genes 1 and 2 (EBI 1 and EBI 2, respectively) can be predicted from their cDNA sequences to encode G protein-coupled peptide receptors. EBI 1 is expressed exclusively in B- and T-lymphocyte cell lines and in lymphoid tissues and is highly homologous to the interleukin 8 receptors. EBI 2 is most closely related to the thrombin receptor. EBI 2 is expressed in B-lymphocyte cell lines and in lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. EBI 2 is also expressed at lower levels in a promyelocytic and a histiocytic cell line and in pulmonary tissue. These predicted G protein-coupled peptide receptors are more likely to be mediators of EBV effects on B lymphocytes or of normal lymphocyte functions than are genes previously known to be up-regulated by EBV infection.
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收藏
页码:2209 / 2220
页数:12
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