RUMBRIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY AUXARTHRON-UMBRINUM .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES

被引：17

作者：

YAMAGISHI, Y

MATSUOKA, M

ODAGAWA, A

KATO, S

SHINDO, K

MOCHIZUKI, J

机构：

[1] Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma 370-12, 3 Miyahara-cho, Takasaki-shi

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 06期

关键词：

D O I：

10.7164/antibiotics.46.884

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rumbrin has been isolated from a fungus, Auxarthron umbrinum, by a screening program designed to find microorganism-produced cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as fine red needles. Rumbrin prevented cell death caused by calcium overload and exhibited a potent inhibitory activity against lipid peroxidation.

引用

页码：884 / 887

页数：4

共 6 条

[1] NEW ANTI-ISCHAEMIC DRUGS - CYTOPROTECTIVE ACTION WITH NO PRIMARY HEMODYNAMIC-EFFECTS [J].