REGULATION OF THE INTERFERON-INDUCIBLE EIF-2-ALPHA PROTEIN-KINASE BY SMALL RNAS

被引：55

作者：

CLEMENS, MJ

LAING, KG

JEFFREY, IW

SCHOFIELD, A

SHARP, TV

ELIA, A

MATYS, V

JAMES, MC

TILLERAY, VJ

机构：

[1] Division of Biochemistry, Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, SW17 ORE, Cranmer Terrace

来源：

BIOCHIMIE | 1994年 / 76卷 / 08期

基金：

英国惠康基金;

关键词：

DOUBLE-STRANDED RNA; PROTEIN SYNTHESIS; ADENOVIRUS; EPSTEIN-BARR VIRUS; GROWTH REGULATION;

D O I：

10.1016/0300-9084(94)90081-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes the structure and function of the double-stranded RNA-dependent protein kinase (PKR) and its interaction with RNA activators and inhibitors. The abilities of small virally-encoded RNAs such as VA, RNA of adenovirus, the Epstein-Barr virus encoded (EBER) RNAs and the Tat-responsive region RNA of HIV-1 to bind to and regulate PKR are reviewed, and the physiological implications of such regulation for the control of viral replication and cell growth are discussed. The potential effects on the activity of PKR of other proteins that bind double-stranded RNA and/or small viral and cellular RNAs are also considered.

引用

页码：770 / 778

页数：9

共 92 条

[1] CHARACTERIZATION OF THE MAJOR EPSTEIN-BARR VIRUS-SPECIFIC RNA IN BURKITT LYMPHOMA-DERIVED CELLS [J].

ARRAND, JR ;

RYMO, L .

JOURNAL OF VIROLOGY, 1982, 41 (02) :376-389

[2] THE MOUSE ANTIPHOSPHOTYROSINE IMMUNOREACTIVE KINASE, TIK, IS INDISTINGUISHABLE FROM THE DOUBLE-STRANDED RNA-DEPENDENT, INTERFERON-INDUCED PROTEIN-KINASE, PKR [J].

BAIER, LJ ;

SHORS, T ;

SHORS, ST ;

JACOBS, BL .

NUCLEIC ACIDS RESEARCH, 1993, 21 (20) :4830-4835

[3] TRANSLATIONAL REGULATION BY THE INTERFERON-INDUCED DOUBLE-STRANDED-RNA-ACTIVATED 68-KDA PROTEIN-KINASE [J].

BARBER, GN ;

WAMBACH, M ;

WONG, ML ;

DEVER, TE ;

HINNEBUSCH, AG ;

KATZE, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4621-4625

[4] CHROMOSOMAL ASSIGNMENT OF THE INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN-KINASE (PRKR) TO HUMAN CHROMOSOME-2P21-P22 AND MOUSE CHROMOSOME-17 E2 [J].

BARBER, GN ;

EDELHOFF, S ;

KATZE, MG ;

DISTECHE, CM .

GENOMICS, 1993, 16 (03) :765-767

[5] FUNCTIONAL EXPRESSION AND CHARACTERIZATION OF THE INTERFERON-INDUCED DOUBLE-STRANDED-RNA ACTIVATED P68 PROTEIN-KINASE FROM ESCHERICHIA-COLI [J].

BARBER, GN ;

TOMITA, J ;

HOVANESSIAN, AG ;

MEURS, E ;

KATZE, MG .

BIOCHEMISTRY, 1991, 30 (42) :10356-10361

[6] DETECTION OF PROTEIN-KINASE HOMOLOGS AND VIRAL RNA-BINDING DOMAINS UTILIZING POLYCLONAL ANTISERUM PREPARED AGAINST A BACULOVIRUS-EXPRESSED DS RNA-ACTIVATED 68,000-DA PROTEIN-KINASE [J].

BARBER, GN ;

TOMITA, J ;

GARFINKEL, MS ;

MEURS, E ;

HOVANESSIAN, A ;

KATZE, MG .

VIROLOGY, 1992, 191 (02) :670-679

[7] CONSTRUCTION AND ANALYSIS OF ADDITIONAL ADENOVIRUS SUBSTITUTION MUTANTS CONFIRM THE COMPLEMENTATION OF VAI-RNA FUNCTION BY 2 SMALL RNAS ENCODED BY EPSTEIN-BARR VIRUS [J].

BHAT, RA ;

THIMMAPPAYA, B .

JOURNAL OF VIROLOGY, 1985, 56 (03) :750-756

[8] DEGRADATION OF THE INTERFERON-INDUCED 68,000-MR PROTEIN-KINASE BY POLIOVIRUS REQUIRES RNA [J].

BLACK, TL ;

BARBER, GN ;

KATZE, MG .

JOURNAL OF VIROLOGY, 1993, 67 (02) :791-800

[9]

CATIGNOL A, 1993, MOL CELL BIOL, V13, P2193

[10] IDENTIFICATION OF A CONSERVED MOTIF THAT IS NECESSARY FOR BINDING OF THE VACCINIA VIRUS E3L GENE-PRODUCTS TO DOUBLE-STRANDED-RNA [J].

CHANG, HW ;

JACOBS, BL .

VIROLOGY, 1993, 194 (02) :537-547

← 1 2 3 4 5 6 7 8 9 10 →