TOTAL URINARY AND FREE SERUM HYDROXYPROLINE IN METASTATIC BONE-DISEASE

被引：21

作者：

GASSER, AB ^{[1
]}

DEPIERRE, D ^{[1
]}

COURVOISIER, B ^{[1
]}

机构：

[1] HOP CANTONAL, CTR ETUDE MALAD OSTEO ARTICULAIRES, DEPT MED, CH-1211 GENEVA 4, SWITZERLAND

来源：

BRITISH JOURNAL OF CANCER | 1979年 / 39卷 / 03期

关键词：

D O I：

10.1038/bjc.1979.52

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The possibility of correlation between free serum and urinary total hydroxyproline and whether this correlation can be applied to clinical conditions was examined. The correlation between the 2 indices was 0.80 (P < 0.001) in 18 patients, most of whom suffered from malignant disease. On comparing the same measurements in 37 patients, all with known metastatic bone disease, normal results for free serum hydroxyproline were found in 29/37, whereas only 2/37 values of urinary total hydroxyproline were normal. Urinary total hydroxyproline, measured as the ratio hydroxyproline/creatinine in a fresh specimen of early-morning urine apparently is the best index of collagen breakdown in metastatic bone disease and preferable to measurement of free serum hydroxyproline.

引用

页码：280 / 283

页数：4

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