TRANSPORT OF IONIC SPECIES THROUGH SKIN

被引：14

作者：

PHIPPS, JB

PADMANABHAN, RV

LATTIN, GA

机构：

[1] Medtronic Inc, United States

来源：

SOLID STATE IONICS | 1988年 / 28卷

关键词：

Biological Materials--Skin - Biomaterials--Mass Transfer - Biomedical Engineering--Drug Therapy - Mass Transfer--Electric Field Effects - Organic Compounds--Ionic Conduction;

D O I：

10.1016/0167-2738(88)90460-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The literature pertaining to the transdermal iontophoretic delivery of drugs spans over eighty years. The general definition of iontophoresis is the introduction of ionic species into the body via an applied electric potential for therapeutic purposes. In this review, the structure of the skin is described and evidence that ions migrate along shunt pathways, such as hair follicles and sweat glands, is cited. Finally, experimental data comparing the efficiency of drug delivery through excised pig, rabbit, and human skin for ionic lithium, sodium, magnesium, calcium, potassium, salicylate, pyridostigmine, and propranolol are summarized. The efficiency of drug delivery was found to decrease with increasing molecular weight and to be substantially lower for divalent cations than for monovalent cations of similar molecular weight.

引用

页码：1778 / 1783

页数：6

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