TDT-POSITIVE, SMIG-NEGATIVE-B PRECURSOR CELL LEUKEMIA WITH BURKITT MORPHOLOGY - A CASE-REPORT

被引：9

作者：

INOKUCHI, K ^{[1
]}

KOMIYA, I ^{[1
]}

DAN, K ^{[1
]}

KURIYA, S ^{[1
]}

SHINOHARA, T ^{[1
]}

NOMURA, T ^{[1
]}

机构：

[1] JAPAN RED CROSS,MED CTR,DEPT HUMAN GENET,TOKYO,JAPAN

来源：

LEUKEMIA & LYMPHOMA | 1990年 / 2卷 / 3-4期

关键词：

Acute lymphoblastic leukemia; Burkitt-type; Surface immunoglobulines; Terminal deoxynucleotidyl; Transferase;

D O I：

10.3109/10428199009053532

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The phenotypic marker profile and molecular analysis of ALL with typical FAB-L3 morphology of a 66-year-old lady are described. We detected the phenotypic expression of B cell-associated antigens (B4, BA1, HLA-DR) and terminal deoxynucleotidyl transferase, but not of surface and cytoplasmic immunoglobulin or cALLA antigen. Molecular analysis revealed that immunoglobulin heavy chain gene was in the rearranged form and that T cell βreceptor gene was in the germ-line form Cytomorphology, immunophenotype and genotype indicated that her leukemic cells had characteristics of B-cell precursor ALL of Burkitt type. Cytogenetic investigation showed a normal karyotype, and neither rearrangement nor amplification of c-myc gene was detected To the best of our knowledge this type of TdT-positive, Smlg-negative FAB-L3 with immunological and molecular confirmation has as yet not been reported © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：251 / 255

页数：5

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