FACIOSCAPULOHUMERAL MUSCULAR-DYSTROPHY GENE IN DUTCH FAMILIES IS NOT LINKED TO MARKERS FOR FAMILIAL ADENOMATOUS POLYPOSIS ON THE LONG ARM OF CHROMOSOME-5

被引：13

作者：

WIJMENGA, C

FRANTS, RR

BROUWER, OF

VANDERKLIFT, HM

KHAN, PM

PADBERG, GW

机构：

[1] STATE UNIV LEIDEN HOSP,DEPT NEUROL,RIJNSBURGERWEG 10,2333 AA LEIDEN,NETHERLANDS

[2] LEIDEN STATE UNIV,DEPT HUMAN GENET,2312 AV LEIDEN,NETHERLANDS

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 95卷 / 02期

关键词：

Chromosome; 5; Facioscapulohumeral muscular dystrophy; Familial adenomatous polyposis; Linkage analysis;

D O I：

10.1016/0022-510X(90)90245-I

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cosegregation of facioscapulohumeral muscular dystrophy (FSHD) and familial adenomatous polyposis (FAP) has been described in two small families. The gene for FAP is located on the long arm of chromosome 5. We studied two large Dutch families with FSHD and found no evidence for linkage with gene markers closely linked to FAP. These results strongly suggest that the FSHD gene segregating in the Dutch families is not localized close to the FAP locus on chromosome 5. © 1990.

引用

页码：225 / 229

页数：5

共 14 条

[1]

BLAKE D, 1988, ANN NEUROL, V24, P178

[2]

BLAKE DM, 1989, NEUROLOGY S, V1, P404

[3] LOCALIZATION OF THE GENE FOR FAMILIAL ADENOMATOUS POLYPOSIS ON CHROMOSOME-5 [J].