STRUCTURAL AND FUNCTIONAL CORRELATIONS IN PARATHYROID-HORMONE RESPONSIVE TRANSPLANTABLE OSTEOGENIC SARCOMAS

被引：22

作者：

UNDERWOOD, JCE

MELICK, RA

LOOMES, RS

DANGERFIELD, VM

CRAWFORD, A

COULTON, L

INGLETON, PM

MARTIN, TJ

机构：

[1] UNIV SHEFFIELD,DEPT CLIN PATHOL,SHEFFIELD S10 2RX,S YORKSHIRE,ENGLAND

[2] UNIV SHEFFIELD,DEPT ZOOL,SHEFFIELD S10 2RX,S YORKSHIRE,ENGLAND

[3] UNIV MELBOURNE,ROYAL MELBOURNE HOSP,DEPT MED,MELBOURNE 3050,VICTORIA,AUSTRALIA

来源：

EUROPEAN JOURNAL OF CANCER | 1979年 / 15卷 / 09期

关键词：

D O I：

10.1016/0014-2964(79)90131-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone tumours induced in rats by repeated injections of 32P-orthophosphate exhibit morphological characteristics of osteogenic differentiation after successive transplantation; stromal mineralization is a constant feature. Cell membranes isolated from the transplantable tumour possess a parathyroid hormone (PTH) and prostaglandin (PGE1, PGE2, PGF2α) responsive adenylate cyclase. Basal cyclic AMP (cAMP) concentrations and PTH responsiveness are greatest in the cellular poorly mineralized peripheral zones of the tumour. cAMP and PTH induce a cytoplasmic contraction response in cultured tumour cells and the PTH responsive adenylate cyclase is retained by the cells even after repeated subculture. A direct correlation exists between tumour size and serum alkaline phosphatase activity. © 1979.

引用

页码：1151 / 1158

页数：8

共 29 条

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