DYNAMICS OF SKELETAL PATTERN FORMATION IN DEVELOPING CHICK LIMB

被引:215
作者
NEWMAN, SA
FRISCH, HL
机构
[1] SUNY ALBANY, DEPT BIOL SCI, ALBANY, NY 12222 USA
[2] SUNY ALBANY, DEPT CHEM, ALBANY, NY 12222 USA
[3] SUNY ALBANY, DEPT PHYS, ALBANY, NY 12222 USA
关键词
D O I
10.1126/science.462174
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in discrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex.
引用
收藏
页码:662 / 668
页数:7
相关论文
共 68 条
[1]  
ABBOTT URSULA K., 1960, JOUR HEREDITY, V51, P195
[2]   POSITION-RELATED CAPACITY FOR DIFFERENTIATION OF LIMB MESENCHYME IN CELL-CULTURE [J].
AHRENS, PB ;
SOLURSH, M ;
REITER, RS ;
SINGLEY, CT .
DEVELOPMENTAL BIOLOGY, 1979, 69 (02) :436-450
[3]   HOW WELL DOES TURINGS THEORY OF MORPHOGENESIS WORK [J].
BARD, J ;
LAUDER, I .
JOURNAL OF THEORETICAL BIOLOGY, 1974, 45 (02) :501-531
[4]  
CAIRNS JM, 1977, VERTEBRATE LIMB SOMI, P123
[6]   ALTERATION IN CELL-SURFACE LETS PROTEIN DURING MYOGENESIS [J].
CHEN, LB .
CELL, 1977, 10 (03) :393-400
[7]   STUDIES ON INTER-CELLULAR LETS GLYCOPROTEIN MATRICES [J].
CHEN, LB ;
MURRAY, A ;
SEGAL, RA ;
BUSHNELL, A ;
WALSH, ML .
CELL, 1978, 14 (02) :377-391
[8]  
CHEVALLIER A, 1977, J EMBRYOL EXP MORPH, V41, P245
[9]   EXPERIMENTAL-ANALYSIS OF ORIGIN OF WING MUSCULATURE IN AVIAN EMBRYOS [J].
CHRIST, B ;
JACOB, HJ ;
JACOB, M .
ANATOMY AND EMBRYOLOGY, 1977, 150 (02) :171-186
[10]  
DAWD DS, 1971, J EMBRYOL EXP MORPH, V26, P401