SUBSTANTIA-NIGRA - A SITE OF ACTION OF MUSCLE-RELAXANT DRUGS

被引：26

作者：

TURSKI, L ^{[1
]}

KLOCKGETHER, T ^{[1
]}

SCHWARZ, M ^{[1
]}

TURSKI, WA ^{[1
]}

SONTAG, KH ^{[1
]}

机构：

[1] MAX PLANCK INST EXPTL MED,W-3400 GOTTINGEN,GERMANY

来源：

ANNALS OF NEUROLOGY | 1990年 / 28卷 / 03期

关键词：

D O I：

10.1002/ana.410280307

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sites of action of centrally active muscle relaxant drugs are not well defined. Clinical experience with such drugs suggests that the spinal cord may be one of the important regions from which pathologically increased muscle tone may be relieved. Supraspinal centers that may also be involved in the expression of muscle relaxant action have not yet been defined. We report here that microinjections of therapeutically relevant muscle relaxants into the midbrain tegmentum of genetically spastic rats decrease muscle tone. The substantia nigra is the region from which midazolam, baclofen, and tizanidine (drugs used clinically in the treatment of spasticity), or gamma‐vinyl‐GABA, (−)‐2‐amino‐7‐phosphonoheptanoate, and [D‐pro2‐D‐phe7‐D‐trp9]‐substance P (experimental drugs active in animal models of spasticity), reduce muscle tone in genetically spastic rats and Hoffmann reflexes in normal rats. The effects of muscle relaxant drugs are topographically restricted to the substantia nigra pars reticulata and are receptor specific. These observations disclose a previously unknown function of the substantia nigra in mediating muscle relaxation. Copyright © 1990 American Neurological Association

引用

页码：341 / 348

页数：8

共 41 条

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