RHABDOMYONECROSIS EXPERIMENTALLY INDUCED IN WISTAR RATS BY AFRICANIZED BEE VENOM

被引：20

作者：

AZEVEDOMARQUES, MM

FERREIRA, DB

COSTA, RS

机构：

[1] FAC MED RIBEIRAO PRETO,DEPT PATHOL,BR-14049 RIBEIRAO PRETO,SP,BRAZIL

[2] FAC MED RIBEIRAO PRETO,DEPT INTERNAL MED,BR-14049 RIBEIRAO PRETO,SP,BRAZIL

来源：

TOXICON | 1992年 / 30卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/0041-0101(92)90875-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Damage is reported to skeletal muscle experimentally induced in Wistar rats by Africanized bee venom (ABV). Rhabdomyonecrosis was demonstrated indirectly by increased serum levels of the enzymes aspartate-aminotransferase and total creatine kinase, and directly by necrosis and inflammation observed by standard light microscopy of skeletal muscle. To our knowledge, this is the first report of a systemic damaging effect of ABV on skeletal muscle of experimentally envenomated rats. These data appear to reproduce experimentally some of the findings reported in cases of human envenomation due to multiple Africanized bee stings.

引用

页码：344 / 348

页数：5

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