NONRESPONSIVENESS OF SERUM GONADOTROPINS AND TESTOSTERONE TO PULSATILE GNRH IN HEMOCHROMATOSIS SUGGESTING A PITUITARY DEFECT

被引:15
作者
DURANTEAU, L
CHANSON, P
BLUMBERGTICK, J
THOMAS, G
BRAILLY, S
LUBETZKI, J
SCHAISON, G
BOUCHARD, P
机构
[1] HOP LARIBOISIERE,SERV MED INTERNE ENDOCRINOL,2 RUE A PARE,F-75475 PARIS 10,FRANCE
[2] HOP BICETRE,BIOCHIM LAB,F-94270 LE KREMLIN BICETR,FRANCE
[3] HOP BICETRE,SERV ENDOCRINOL & MALAD REPROD,F-94270 LE KREMLIN BICETR,FRANCE
[4] HOP FERNAND WIDAL,UNITE PHARMACOL CLIN,F-75475 PARIS 10,FRANCE
来源
ACTA ENDOCRINOLOGICA | 1993年 / 128卷 / 04期
关键词
D O I
10.1530/acta.0.1280351
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated the potential pituitary origin of gonadal insufficiency in hemochromatosis. Gonadotropin secretion was studied in seven patients with hemochromatosis and hypogonadism, before and after chronic pulsatile GnRH therapy. Pulsatile LH secretion was studied before (sampling every 10 min for 6 h) and after 15-30 days of chronic pulsatile GnRH therapy (10-12 mug per pulse). Prior to GnRH therapy, all the patients had low serum testosterone, FSH and LH levels. 1,H secretion was non-pulsatile in four patients, while a single pulse was detected in the remaining three. Chronic pulsatile GnRH administration did not increase serum testosterone levels; similarly, serum LH levels remained low: neither pulse frequency nor pulse amplitude was modified. We conclude that hypogonadism in hemochromatosis is due to pituitary lesions.
引用
收藏
页码:351 / 354
页数:4
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