DOGS, DISTEMPER AND PAGETS-DISEASE

被引:35
作者
MEE, AP [1 ]
SHARPE, PT [1 ]
机构
[1] UMDS, GUYS HOSP, DEPT CRANIOFACIAL DEV, LONDON BRIDGE, LONDON SE1 9RT, ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1002/bies.950151203
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cause of Paget's disease is still unknown, despite many years of intensive study. During this time, evidence has sporadically emerged to suggest that the disease may result from a slow viral infection by one or more of the Paramyxoviruses. More recently, epidemiologic and molecular studies have suggested that the canine paramyxovirus, canine distemper virus, is the virus responsible for the disease. If true, then along with rabies, this would be a further example of a canine virus causing human disease. Studies in the natural host have now supported these findings. Further investigations have proposed that the bony abnormalities seen in Paget's disease are due to the effects of the virus on osteoclastic interleukin-6 and c-FOS production, possibly via the transcription factor NF-kappaB.
引用
收藏
页码:783 / 789
页数:7
相关论文
共 70 条
[1]  
AKIRA S, 1992, CHEM IMMUNOL, V51, P299
[2]   IL-6 AND NF-IL6 IN ACUTE-PHASE RESPONSE AND VIRAL-INFECTION [J].
AKIRA, S ;
KISHIMOTO, T .
IMMUNOLOGICAL REVIEWS, 1992, 127 :25-50
[3]  
APPEL MJ, 1987, VIRUS INFECT CARNIVO, P00133
[4]   PAGET DISEASE OF BONE - THE LANCASHIRE FOCUS [J].
BARKER, DJP ;
CHAMBERLAIN, AT ;
GUYER, PB ;
GARDNER, MJ .
BRITISH MEDICAL JOURNAL, 1980, 280 (6222) :1105-1107
[5]   PAGETS-DISEASE OF BONE IN 14 BRITISH TOWNS [J].
BARKER, DJP ;
CLOUGH, PWL ;
GUYER, PB ;
GARDNER, MJ .
BRITISH MEDICAL JOURNAL, 1977, 1 (6070) :1181-1183
[6]  
BARKER DJP, 1985, LANCET, V2, P1245
[7]  
BASLE M, 1983, PATHOL BIOL, V31, P41
[8]   PARAMYXOVIRUS ANTIGENS IN OSTEOCLASTS FROM PAGET BONE TISSUE DETECTED BY MONOCLONAL-ANTIBODIES [J].
BASLE, MF ;
RUSSELL, WC ;
GOSWAMI, KKA ;
REBEL, A ;
GIRAUDON, P ;
WILD, F ;
FILMON, R .
JOURNAL OF GENERAL VIROLOGY, 1985, 66 (OCT) :2103-2110
[9]   MEASLES-VIRUS RNA DETECTED IN PAGETS-DISEASE BONE TISSUE BY INSITU HYBRIDIZATION [J].
BASLE, MF ;
FOURNIER, JG ;
ROZENBLATT, S ;
REBEL, A ;
BOUTEILLE, M .
JOURNAL OF GENERAL VIROLOGY, 1986, 67 :907-913
[10]   STIMULATION OF OSTEOCLASTIC BONE-RESORPTION BY HYDROGEN-PEROXIDE [J].
BAX, BE ;
ALAM, ASMT ;
BANERJI, B ;
BAX, CMR ;
BEVIS, PJR ;
STEVENS, CR ;
MOONGA, BS ;
BLAKE, DR ;
ZAIDI, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (03) :1153-1158