SEARCH FOR A SCHIZOPHRENIA SUSCEPTIBILITY LOCUS ON HUMAN-CHROMOSOME-22

被引：69

作者：

POLYMEROPOULOS, MH

COON, H

BYERLEY, W

GERSHON, ES

GOLDIN, L

CROW, TJ

RUBENSTEIN, J

HOFF, M

HOLIK, J

SMITH, AM

SHIELDS, G

BASS, NJ

POULTER, M

LOFTHOUSE, R

VITA, A

MORGANTI, C

MERRIL, CR

DELISI, LE

机构：

[1] NIMH,BIOCHEM GENET LAB,WASHINGTON,DC

[2] UNIV UTAH,MED CTR,DEPT PSYCHIAT,SALT LAKE CITY,UT

[3] SUNY STONY BROOK,DEPT PSYCHIAT,STONY BROOK,NY 11794

[4] CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND

[5] UNIV MILAN,MILAN,ITALY

[6] NIMH,CLIN NEUROGENET BRANCH,BETHESDA,MD 20892

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1994年 / 54卷 / 02期

关键词：

LINKAGE; SIB-PAIR; AFFECTED PEDIGREE METHOD; SCHIZOPHRENIA;

D O I：

10.1002/ajmg.1320540203

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We used 10 highly informative DNA polymorphic markers and genetic linkage analysis to examine whether a gene locus predisposing to schizophrenia is located on chromosome 22, in 105 families with schizophrenia and schizoaffective disorder. The LOD score method, including analysis for heterogeneity, provided no conclusive evidence of linkage under a dominant, recessive, or penetrance free model of inheritance. Affected sib-pair analysis was inconclusive. Affected pedigree member analysis gave only suggestive evidence for linkage. Multipoint APM analysis, using 4 adjacent loci including D22S281 and IL2RB, a region of interest from the APM analysis, gave non-significant results for the three different weighting functions. (C) 1994 Wiley-Liss, Inc.

引用

页码：93 / 99

页数：7

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