INTERFERON-INDUCED DSRNA-ACTIVATED PROTEIN-KINASE (PKR) - ANTIPROLIFERATIVE, ANTIVIRAL AND ANTITUMORAL FUNCTIONS

被引：48

作者：

HOVANESSIAN, AG

机构：

[1] Unité de Virologie et Immulogie Cellulaire, UA CNRS 1157, Institut Pasteur, 75015 Paris, 25, rue du Dr Roux

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 04期

关键词：

INTERFERON; DSRNA; PROTEIN KINASE; EIF-2; YEAST GCN2 KINASE; TUMOR SUPPRESSOR; 2'; 5' OLIGOADENYLATE SYNTHETASE;

D O I：

10.1006/smvy.1993.1020

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a serine/threonine kinase induced in mammalian cells by interferon. It is responsible for the phosphorylation of the protein synthesis initiation factor eIF-2, thus mediating inhibition of protein synthesis. Studies on the expression of the human protein kinase in the yeast Saccharomyces cerevisae and in murine NIH 3T3 cells, provided evidence for the antiproliferative, antiviral and antitumoral functions of this dsRNA activated protein kinase. © 1993 Academic Press. All rights reserved.

引用

页码：237 / 245

页数：9

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