NOVEL NON-NUCLEOSIDIC PHOSPHORAMIDITE BUILDING-BLOCKS FOR VERSATILE FUNCTIONALIZATION OF OLIGONUCLEOTIDES AT PRIMARY HYDROXY-GROUPS

被引：14

作者：

HOVINEN, J

GUZAEV, A

AZHAYEV, A

LONNBERG, H

机构：

[1] Department of Chemistry, University of Turku

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 19期

关键词：

D O I：

10.1039/p19940002745

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of two non-nucleosidic phosphoramidite building blocks, 1a, b, that enable attachment of various tether groups to oligonucleotides at their 5'-terminus (or 1'-OH of 3'-deoxypsico-nucleoside units) is described. Introduction of these linkers during the oligonucleotide assembly on a solid support, and their subsequent derivatization upon deprotection, afforded amino-, carboxy-, and sulfanyl-alkyl-thethered oligonucleotides.

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页码：2745 / 2749

页数：5

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