CYCLOSPORINES FROM TOLYPOCLADIUM-TERRICOLA

被引：29

作者：

JEGOROV, A

MATHA, V

SEDMERA, P

HAVLICEK, V

STUCHLIK, J

SEIDEL, P

SIMEK, P

机构：

[1] GALENA CO,RES UNIT,CR-37005 CESKE BUDEJOVICE,CZECH REPUBLIC

[2] ACAD SCI CZECH REPUBL,INST MICROBIOL,CR-14220 PRAGUE,CZECH REPUBLIC

[3] GALENA CO,R&D,CR-74770 OPAVA,CZECH REPUBLIC

[4] ACAD SCI CZECH REPUBL,INST ENTOMOL,ANALYT CHEM LAB,CR-37005 CESKE BUDEJOVICE,CZECH REPUBLIC

来源：

PHYTOCHEMISTRY | 1995年 / 38卷 / 02期

关键词：

TOLYPOCLADIUM TERRICOLA; FUNGI IMPERFECTI; CYCLOSPORINES;

D O I：

10.1016/0031-9422(94)00711-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New natural cyclosporins were isolated from the mycelium of surface cultivated fungus Tolypocladium terricola. The chemical structures of [Leu(4)] CS and [MeLeu(1)] CS = cyclosporin-J, were deduced from the NMR and mass spectral data. Biological activity of new cyclosporins is reported based on the proliferative mitogen stimulation test.

引用

页码：403 / 407

页数：5

共 17 条

[1] PRODUCTION OF EXTRACELLULAR ENZYMES AND CYCLOSPORINE BY TOLYPOCLADIUM-INFLATUM AND MORPHOLOGICALLY RELATED FUNGI [J].