BROMINATED BIS(INDOLE) ALKALOIDS FROM THE MARINE SPONGE HEXADELLA SP

被引：156

作者：

MORRIS, SA

ANDERSEN, RJ

机构：

[1] UNIV BRITISH COLUMBIA,DEPT CHEM,VANCOUVER V6T 1W5,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT OCEANOG,VANCOUVER V6T 1W5,BC,CANADA

来源：

TETRAHEDRON | 1990年 / 46卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4020(01)81355-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Topsentin C (7), dragmacidon A (8) and dragmacidon B (9), three new brominated bis(indole) alkaloids, have been isolated from the Pacific Ocean sponge Hexadella sp. collected off the coast of British Columbia. The proposed structures for 7, 8 and 9 are based on spectroscopic analysis. Dragmacidon A (8) showed significant cytotoxicity in the L1210 assay. © 1990.

引用

收藏

页码：715 / 720

页数：6

相关论文

共 8 条

[1]

Austin W.C., 1985, ANNOTATED CHECKLIST

[2] TOPSENTINS, NEW TOXIC BIS-INDOLE ALKALOIDS FROM THE MARINE SPONGE TOPSENTIA-GENITRIX [J].

BARTIK, K ;

BRAEKMAN, JC ;

DALOZE, D ;

STOLLER, C ;

HUYSECOM, J ;

VANDEVYVER, G ;

OTTINGER, R .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1987, 65 (09) :2118-2121

[3]

BERGQUIST PR, 1983, MARINE NATURAL PRODU, V5, pCH1

[4] DRAGMACIDIN, A NEW CYTO-TOXIC BIS(INDOLE) ALKALOID FROM A DEEP-WATER MARINE SPONGE, DRAGMACIDON SP [J].

KOHMOTO, S ;

KASHMAN, Y ;

MCCONNELL, OJ ;

RINEHART, KL ;

WRIGHT, A ;

KOEHN, F .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (13) :3116-3118

[5]

Kozloff EN, 1987, MARINE INVERTEBRATES

[6] NITROGENOUS METABOLITES FROM THE DEEP-WATER SPONGE HEXADELLA SP [J].

MORRIS, SA ;

ANDERSEN, RJ .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1989, 67 (04) :677-681

[7] FASCAPLYSIN, AN UNUSUAL ANTIMICROBIAL PIGMENT FROM THE MARINE SPONGE FASCAPLYSINOPSIS SP [J].

ROLL, DM ;

IRELAND, CM ;

LU, HSM ;

CLARDY, J .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (14) :3276-3278

[8] TOPSENTIN, BROMOTOPSENTIN, AND DIHYDRODEOXYBROMOTOPSENTIN - ANTIVIRAL AND ANTITUMOR BIS(INDOLYL)IMIDAZOLES FROM CARIBBEAN DEEP-SEA SPONGES OF THE FAMILY HALICHONDRIIDAE - STRUCTURAL AND SYNTHETIC STUDIES [J].

TSUJII, S ;

RINEHART, KL ;

GUNASEKERA, SP ;

KASHMAN, Y ;

CROSS, SS ;

LUI, MS ;

POMPONI, SA ;

DIAZ, MC .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (23) :5446-5453