ACETYLATION PHENOTYPES AND BLADDER-CANCER

被引:41
作者
HANKE, J
KRAJEWSKA, B
机构
[1] The Department of Laboratory Diagnostics, Nofer's Institute of Occupational Medicine, Lodz, 90-950
关键词
D O I
10.1097/00043764-199009000-00032
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The human population consists of slow and fast aaetylators. To test the hypothesis that slow aoetylators are predisposed to bladder cancer caused by exposure to aromatic amines, we performed a retrospective study, phenotyping cancer patients. Bladder cancer patients were divided, based on interview data, into two groups: Those with and without occupational exposure to aromatic amines. The nonexposed group had a distribution of slow acetylators (60.5%) similar to that in the general Polish population. (A group of controls was 45.4% slow acetylators.) The exposed group was predominantly slow acetylators (87.6%). A prospective study in a currently healthy ocoupationally exposed cohort has been initiated to investigate possible change in acetylator phenotype with disease or therapy onset. Cohort members have been typed for acetylator status; a tumor marker (to identify bladder cancer at a preolinical stage) and acetylator status will be measured periodically. © by American College of Occupational Medicine.
引用
收藏
页码:917 / 918
页数:2
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