QSAR APPROACH TO UNDERSTAND THE ANTITUMOR-ACTIVITY OF ORGANOTINS

The activity of a series of diorganotin(IV) salts and complexes against murine leukaemia P388 (log(T/C)) is correlated to the lipophilicity (log P) of the organic radicals bound to the metal, as well as of radicals plus ligands in thiolato complexes. Compounds R2Snhal2, the related oxo and hydroxo derivatives, complexes R2SnX2. L2 and R2SnL3,4 (L being ligands with N and O donor atoms), and compounds with S-Sn bonds, R2Sn(SR') and R2Sn(SR')2, seem to originate three congeneric series, described by parabolic functions log(T/C) versus log P, the latter estimated for the organic radicals in R2Sn(IV). Compounds R2Sn(SR') yield an additional parabolic function, where log P concerns both R and SR'.