CDNA CLONING OF THE HMGI-C PHOSPHOPROTEIN, A NUCLEAR-PROTEIN ASSOCIATED WITH NEOPLASTIC AND UNDIFFERENTIATED PHENOTYPES

被引：172

作者：

MANFIOLETTI, G

GIANCOTTI, V

BANDIERA, A

BURATTI, E

SAUTIERE, P

CARY, P

CRANEROBINSON, C

COLES, B

GOODWIN, GH

机构：

[1] CNRS,INST RECH CANC,F-59045 LILLE,FRANCE

[2] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

[3] MIDDLESEX HOSP,CRC,MOLEC TOXICOL RES GRP,LONDON W1,ENGLAND

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 24期

关键词：

D O I：

10.1093/nar/19.24.6793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HMGI-C protein is a nuclear phosphoprotein expressed at high levels in transformed cells. The CDNA encoding the mouse protein has been isolated and the sequence of the encoded protein shows that it is related to the HMGY and I proteins, proteins which bind in the minor groove of DNA containing stretches of A and T. The HMGI-C protein has three short highly basic domains, an acidic C-terminal domain, and potential CDC2/p34 and casein kinase II phosphorylation sites. Analysis of mRNA levels demonstrate that the HMGI-C gene is not expressed in a variety of mouse tissues but is expressed in Lewis lung carcinoma cells.

引用

页码：6793 / 6797

页数：5

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