ENZYME-CATALYZED OLIGOSACCHARIDE SYNTHESIS

被引:277
作者
ICHIKAWA, Y
LOOK, GC
WONG, CH
机构
[1] Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037
关键词
D O I
10.1016/0003-2697(92)90099-S
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Cell-surface carbohydrates and their conjugates are involved in many types of molecular recognition. This review describes recent developments in enzyme-catalyzed oligosaccharide synthesis, with particular focus on glycosyltransferase and glycosidase reactions. With the increasing availability of glycosyltransferases via recombinant DNA technology, glycosyltransferase-catalyzed glycosylation with in situ regeneration of sugar nucleotides appears to be the most effective method for large-scale stereocontrolled oligosaccharide synthesis. © 1992.
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页码:215 / 238
页数:24
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