A CONTROLLED-STUDY OF HUMAN CHORIONIC-GONADOTROPIN INDUCED OVULATION VERSUS URINARY LUTEINIZING-HORMONE SURGE FOR TIMING OF INTRAUTERINE INSEMINATION

被引：26

作者：

MARTINEZ, AR

BERNADUS, RE

VOORHORST, FJ

VERMEIDEN, JPW

SCHOEMAKER, J

机构：

[1] Division of Reproductive Endocrinology and Fertility, Department of Obstetrics and Gynaecology, Free University Hospital, 1007 MB Amsterdam

[2] Department of Theory of Medicine, Epidemiology and Biostatistics, Free University Hospital, 1007 MB Amsterdam

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 09期

关键词：

IUI; LH TEST; HCG; OVULATION TIMING;

D O I：

10.1093/oxfordjournals.humrep.a137521

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Forty-eight patients in a programme of intrauterine insemination (IUI) were randomized in a cross-over study. All were stimulated with clomiphene citrate (CC) and inseminated either after follicular rupture induced by human chorionic gonadotrophin (HCG) or after a spontaneous urinary luteinizing hormone (LH) surge. The HCG was administered when follicles of 18-22 mm in diameter were observed on ultrasound and IUI was performed 37-40 h thereafter. The monitoring of a urinary LH peak was carried out using a rapid urinary LH test. IUI took place approximately 22 h after detection of the LH surge. Overall, the pregnancy rates were 9.3% (4/43) after HCG induced ovulation and 20.5% (9/44) after spontaneous ovulation (P = 0. 12). Analysis of mid-cycle events showed that following sonographic criteria, the HCG injection was performed significantly earlier in the cycle compared with the spontaneous LH surge. In addition, the mean diameter of the preovulatory follicles was significantly smaller and insemination was substantially earlier in the HCG induced cycles. These findings suggest that a beneficial effect arises from allowing the natural process of final follicular maturation to occur.

引用

页码：1247 / 1251

页数：5

共 22 条

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