KARYOTYPE INSTABILITY IN MYELODYSPLASTIC SYNDROMES - A SPECIFIC STEP IN PATHOGENESIS PRECEDING CLONAL CHROMOSOME-ANOMALIES

被引：16

作者：

HAASE, D

FONATSCH, C

FREUND, M

机构：

[1] Arbeitsgruppe Tumorcytogenetik, Institut für Humangenetik, Medizinische Universität zu Lübeck, Lübeck

[2] Abteilung Hämatologie/Onkologie, Medizinische Hochschule Hannover, Hannover

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 8卷 / 03期

关键词：

CARCINOGENESIS; CYTOGENETICS; KARYOTYPE INSTABILITY; MYELODYSPLASTIC SYNDROMES;

D O I：

10.3109/10428199209054908

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a prospective study, 20 (11.6%) out of 172 patients with myelodysplastic syndromes (MDS) and two patients with aplastic anemia showed an increased spontaneous karyotype instability. No clonal chromosomal aberrations were detectable at the time of first examination. In three patients clonal anomalies developed during the course of the disease. In 17 out of 22 cases (77.2%) chromosomes 1, 5 or 7 were involved in nonclonal anomalies. The same chromosomes were frequently affected in patients with clonal abnormalities too. Our data suggest that spontaneous karyotype instability may be specific to a high proportion of cases with MDS and may constitute the source of clonal chromosome anomalies in these disorders.

引用

页码：221 / 228

页数：8

共 17 条

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