NEW TECHNIQUE IN OPTICAL RESOLUTIONS

被引：9

作者：

ACS, M

MRAVIK, A

FOGASSY, E

BOCSKEI, Z

机构：

[1] TECH UNIV BUDAPEST,DEPT ORGAN CHEM TECHNOL,H-1521 BUDAPEST,HUNGARY

[2] TECH UNIV BUDAPEST,INST GEN & ANALYT CHEM,BUDAPEST,HUNGARY

[3] CHINOIN CHEM & PHARMACEUT WORKS LTD,H-1325 BUDAPEST,HUNGARY

来源：

CHIRALITY | 1994年 / 6卷 / 04期

关键词：

AMPHETAMINE; DISTILLATION METHOD; CLATHRATE; OPTICAL ACTIVATION OF BASES;

D O I：

10.1002/chir.530060415

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present paper illustrates the development of an advanced technique in optical resolution. Both of the amphetamine enantiomers can be obtained by a two-step distillation in nearly quantitative yield without any loss of the resolving agent. It is proved that the second-order interactions (H-bond) are sufficient for separation of enantiomers by distillation. (C) 1994 Wiley-Liss, Inc.

引用

页码：314 / 320

页数：7

共 6 条

[1] NEW METHOD OF OPTICAL ACTIVATION FOR RACEMIC BASES [J].