POSITRON EMISSION TOMOGRAPHY AND HISTOPATHOLOGY IN CREUTZFELDT-JAKOB-DISEASE

被引：29

作者：

GOLDMAN, S

LIARD, A

FLAMENTDURAND, J

LUXEN, A

BIDAUT, LM

STANUS, E

HILDEBRAND, J

PRZEDBORSKI, S

机构：

[1] ULB,HOP ERASME,SERV NEUROL,BRUSSELS,BELGIUM

[2] ULB,HOP ERASME,SERV ANAT PATHOL,BRUSSELS,BELGIUM

来源：

NEUROLOGY | 1993年 / 43卷 / 09期

关键词：

D O I：

10.1212/WNL.43.9.1828

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied a 62-year-old man with Creutzfeldt-Jakob disease (CJD), using positron emission tomography (PET) and (F-18)-2-fluoro-2-deoxy-D-glucose (FDG). Glucose metabolism was heterogeneously decreased throughout the brain. At autopsy, regional distributions of spongiosis, astrogliosis, and neuronal loss correlated with premortem regional metabolic deficits. These results suggest that PET with FDG may provide metabolic regional markers for CJD neuropathology.

引用

收藏

页码：1828 / 1830

页数：3

相关论文

共 10 条

[1] CREUTZFELDT-JAKOB DISEASE - CLINICAL ANALYSIS OF A CONSECUTIVE SERIES OF 230 NEUROPATHOLOGICALLY VERIFIED CASES [J].

BROWN, P ;

CATHALA, F ;

CASTAIGNE, P ;

GAJDUSEK, DC .

ANNALS OF NEUROLOGY, 1986, 20 (05) :597-602

[2] REGIONAL CEREBRAL OXYGEN-SUPPLY AND UTILIZATION IN DEMENTIA - A CLINICAL AND PHYSIOLOGICAL STUDY WITH O-15 AND POSITRON TOMOGRAPHY [J].

FRACKOWIAK, RSJ ;

POZZILLI, C ;

LEGG, NJ ;

DUBOULAY, GH ;

MARSHALL, J ;

LENZI, GL ;

JONES, T .

BRAIN, 1981, 104 (DEC) :753-778

[3] BITEMPORAL HYPOMETABOLISM IN CREUTZFELDT-JAKOB DISEASE MEASURED BY POSITRON EMISSION TOMOGRAPHY WITH [F-18] 2-FLUORODEOXYGLUCOSE [J].

FRIEDLAND, RP ;

PRUSINER, SB ;

JAGUST, WJ ;

BUDINGER, TF ;

DAVIS, RL .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1984, 8 (05) :978-981

[4] POSITRON EMISSION TOMOGRAPHY IN CREUTZFELDT-JAKOB DISEASE [J].

HOLTHOFF, VA ;

SANDMANN, J ;

PAWLIK, G ;

SCHRODER, R ;

HEISS, WD .

ARCHIVES OF NEUROLOGY, 1990, 47 (09) :1035-1038

[5] EVALUATION OF CEREBRAL BIOPSIES FOR THE DIAGNOSIS OF DEMENTIA [J].

HULETTE, CM ;

EARL, NL ;

CRAIN, BJ .

ARCHIVES OF NEUROLOGY, 1992, 49 (01) :28-31

[6] ATAXIC CREUTZFELDT-JAKOB DISEASE - DIAGNOSTIC-TECHNIQUES AND NEUROPATHOLOGIC OBSERVATIONS IN EARLY DISEASE [J].

JONES, HR ;

HEDLEYWHYTE, ET ;

FREIDBERG, SR ;

BAKER, RA .

NEUROLOGY, 1985, 35 (02) :254-257

[7] POSITRON EMISSION TOMOGRAPHY AND HISTOPATHOLOGY IN PICKS DISEASE [J].

KAMO, H ;

MCGEER, PL ;

HARROP, R ;

MCGEER, EG ;

CALNE, DB ;

MARTIN, WRW ;

PATE, BD .

NEUROLOGY, 1987, 37 (03) :439-445

[8] COMPARISON OF PET, MRI, AND CT WITH PATHOLOGY IN A PROVEN CASE OF ALZHEIMERS-DISEASE [J].

MCGEER, PL ;

KAMO, H ;

HARROP, R ;

MCGEER, EG ;

MARTIN, WRW ;

PATE, BD ;

LI, DKB .

NEUROLOGY, 1986, 36 (12) :1569-1574

[9] TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC-RATE IN HUMANS WITH (F-18)2-FLUORO-2-DEOXY-D-GLUCOSE - VALIDATION OF METHOD [J].

PHELPS, ME ;

HUANG, SC ;

HOFFMAN, EJ ;

SELIN, C ;

SOKOLOFF, L ;

KUHL, DE .

ANNALS OF NEUROLOGY, 1979, 6 (05) :371-388

[10]

SHIH WJ, 1987, J NUCL MED, V28, P1484