SPONTANEOUS RENAL-CELL TUMORS IN LONG-EVANS CINNAMON RATS

被引：13

作者：

IZUMI, K

KITAURA, K

CHONE, Y

TATE, H

NAKAGAWA, T

SUZUKI, Y

MATSUMOTO, K

机构：

[1] UNIV TOKUSHIMA, SCH MED, DEPT HYG, TOKUSHIMA 770, JAPAN

[2] UNIV TOKUSHIMA, SCH MED, INST ANIM EXPERIMENTAT, TOKUSHIMA 770, JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1994年 / 85卷 / 06期

关键词：

LEC RAT; COPPER TOXICITY; RENAL CELL CARCINOMA;

D O I：

10.1111/j.1349-7006.1994.tb02396.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoplastic lesions of the kidneys in untreated Long-Evans Cinnamon (LEC) rats of 57-118 weeks old (85 males and 34 females) and male F344 rats of 64-93 weeks old (59 males) were examined histologically. The incidences of renal cell tumors in male and female LEC rats were 6/80 (8%) in weeks 57-65, 3/19 (16%) in weeks 66-75, 3/8 (38%) in weeks 76-105 and 7/12 (58%) in weeks 106-118. Of these tumors, 13 were microscopic adenomas and 7 were renal cell carcinomas. The copper content of the kidneys was about three times higher in LEC rats than in F344 rats (P < 0.001), but the iron content of the kidneys was similar in the two strains.

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收藏

页码：563 / 566

页数：4

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