SCANNING-TUNNELING-MICROSCOPY STUDIES OF BETA-AMYLOID FIBRIL STRUCTURE AND ASSEMBLY

被引：16

作者：

SHIVJI, AP

BROWN, F

DAVIES, MC

JENNINGS, KH

ROBERTS, CJ

TENDLER, SJB

WILKINSON, MJ

WILLIAMS, PM

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,BIOPHYS & SURFACE ANAL LAB,NOTTINGHAM NG7 2RD,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT NEUROSCI,HARLOW CM19 5AD,ESSEX,ENGLAND

[3] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

FEBS LETTERS | 1995年 / 371卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

ALZHEIMERS DISEASE; BETA-AMYLOID; AGGREGATION; SCANNING TUNNELING MICROSCOPY;

D O I：

10.1016/0014-5793(95)00858-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is in part characterised by the deposit of beta-amyloid peptide in the form of fibrils in the brain, In this study, the scanning tunnelling microscope (STM) has been used to provide high resolution images of synthetic fibril structure and formation as a function of time, Short fibrils are observed following brief peptide incubation times. At longer incubation periods ribbon like filaments were observed. These results suggest that beta-amyloid self-assembly is an ordered process, with a correlation between time of incubation and length of beta-amyloid filament growth.

引用

页码：25 / 28

页数：4

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