PROTEIN-KINASE-C INHIBITORS - NOVEL SPIROSESQUITERPENE ALDEHYDES FROM A MARINE SPONGE AKA (=SIPHONODICTYON) CORALLIPHAGUM

被引：37

作者：

CHAN, JA

FREYER, AJ

CARTE, BK

HEMLING, ME

HOFMANN, GA

MATTERN, MR

MENTZER, MA

WESTLEY, JW

机构：

[1] Research and Development, SmithKline Beecham Pharmaceuticals, Pennsylvania 19406-0939, P.O. Box 1539, King of Prussia

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1994年 / 57卷 / 11期

关键词：

D O I：

10.1021/np50113a011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibit ors of protein kinase C.

引用

页码：1543 / 1548

页数：6

共 4 条

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[2]

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[3] IDENTIFICATION OF THE STRUCTURES OF MULTIPLE SUBSPECIES OF PROTEIN-KINASE-C EXPRESSED IN RAT-BRAIN [J].

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ONO, Y ;

OGITA, K ;

FUJII, T ;

ASAOKA, Y ;

SEKIGUCHI, K ;

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IGARASHI, K ;

NISHIZUKA, Y .

FEBS LETTERS, 1987, 217 (02) :227-231

[4]

SULLIVAN B, 1980, TETRAHEDRON, V37, P979

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