INDUCTION OF MYELIN-ASSOCIATED GLYCOPROTEIN MESSENGER-RNA IN EXPERIMENTAL REMYELINATION

被引：22

作者：

FUJITA, N ^{[1
]}

ISHIGURO, H ^{[1
]}

SATO, S ^{[1
]}

KURIHARA, T ^{[1
]}

KUWANO, R ^{[1
]}

SAKIMURA, K ^{[1
]}

TAKAHASHI, Y ^{[1
]}

MIYATAKE, T ^{[1
]}

机构：

[1] NIIGATA UNIV,BRAIN RES INST,DEPT NEUROPHARMACOL,NIIGATA 951,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 513卷 / 01期

关键词：

2′; 3′-Cyclic-nucleotide; 3′-phosphodiesterase; Alternative splicing; Cuprizone; Myelin-associated glycoprotein; Remyelination;

D O I：

10.1016/0006-8993(90)91102-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two forms of myelin-associated glycoprotein (MAG) mRNA are produced by alternative splicing of the exon 12 portion. Expression of the two forms of MAG mRNA was studied here in experimentally introduced demyelination and remyelination by Cuprizone intoxication. During the demyelinating stage, both forms of MAG mRNA decreased markedly. When feeding with Cuprizone was stopped, MAG mRNA began to increase. One form of MAG mRNA without the exon 12 portion, which appears in normal development at the period of active myelination, was characteristically induced during the remyelinating stage. The other form containing the exon 12 portion was also induced but recovered only to the level in normal development. © 1990.

引用

页码：152 / 155

页数：4

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