ROLE OF THYROID STIMULATING HORMONE SUPPRESSION IN THE MANAGEMENT OF THYROID-CANCER

被引:11
作者
THOMAS, CG
机构
[1] Department of Surgery, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill
来源
SEMINARS IN SURGICAL ONCOLOGY | 1991年 / 7卷 / 02期
关键词
PAPILLARY; FOLLICULAR; HURTHLE CELL TUMORS; TSH SUPPRESSION; TSH TEST; HYPERTHYROXINEMIA;
D O I
10.1002/ssu.2980070213
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Well-differentiated thyroid cancers (papillary, follicular, and some Hurthle cell tumors) contain membrane receptors for TSH. Responsiveness of these tumors to TSH stimuli is documented by increased radioactive iodine uptake, secretion of thyroglobulin, increase in thyroid size, and potential progression to an anaplastic type. Although TSH suppression has a variable effect on the growth of existing tumors and the incidence of recurrent disease, there is a sound rationale for long-term TSH suppression in all patients with differentiated tumors of the thyroid. The ultra-sensitive TSH test permits ready monitoring of the adequacy of thyroxine dosage. The cost is minimal (approximately $.10/day) and the risks are negligible if one assumes the avoidance of hyperthyroxinemia.
引用
收藏
页码:115 / 119
页数:5
相关论文
共 49 条
[1]  
Siverberg E, Lubera J, Cancer statistics, Cancer, 39, pp. 3-20, (1989)
[2]  
Surveillance epidemiology, and end results: Incidence and mortality data: 1973–77, Natl Cancer Inst Monogr, 57, pp. 1-1082, (1981)
[3]  
Mc Conahey WM, Thyroid cancer at the Mayo Clinic, Mayo Clin Proc, 59, (1984)
[4]  
Hay ID, Grant CS, Taylor WF, Mc Conahey WM, Ipsilateral lobectomy versus bilateral lobar resection in papillary thyroid cancer: A retrospective analysis of surgical outcome using a novel prognostic scoring system, Surgery, 102, pp. 1088-1095, (1987)
[5]  
Cady B, Sedgwick C, Meissner W, Et al., Risk factor analysis in differentiated thyroid cancer, Cancer, 43, pp. 810-817, (1979)
[6]  
Buckwalter JA, Thomas CG, Selection of surgical treatment for well differentiated thyroid carcinoma, Ann Surg, 176, pp. 565-578, (1972)
[7]  
Tubiana M, Schlumberger M, Rougier P, Laplanche A, Et al., Long term results and prognostic factors in patient with differentiated thyroid carcinoma, Cancer, 55, pp. 794-894, (1985)
[8]  
Scott RE, Willie JJ, Wier ML, Mechanisms for the initiation and promotion of carcinogenesis: A review and a new concept, Mayo Clin Proc, 59, pp. 107-117, (1984)
[9]  
Thomas CG, pp. 229-247, (1964)
[10]  
Hall IV, Role of initiating and promoting factors in pathogenesis of tumors of the thyroid, British Journal of Cancer, 2, pp. 273-280, (1948)