EFFECTS OF FLUOXETINE AND CA-ACETYL-HOMOTAURINATE ON ALCOHOL INTAKE IN FAMILIAL AND NONFAMILIAL ALCOHOLIC PATIENTS

被引:45
作者
GERRA, G [1 ]
CACCAVARI, R [1 ]
DELSIGNORE, R [1 ]
BOCCHI, R [1 ]
FERTONANI, G [1 ]
PASSERI, M [1 ]
机构
[1] UNIV PARMA,IST CLIN MED GEN & TERAPIA MED,I-43100 PARMA,ITALY
来源
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1992年 / 52卷 / 02期
关键词
D O I
10.1016/S0011-393X(05)80480-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We evaluated the ability of fluoxetine, an inhibitor of serotonin uptake, and Ca-acetyl-homotaurinate, a GABAergic derivative of taurine, to counteract ethanol intake in familial and nonfamilial alcoholic patients. Fluoxetine, homotaurinate, or placebo were administered for 1 month each, in random order, to both groups of patients. The mean number of alcoholic drinks were measured during the 2 weeks before treatment (baseline) and during the 3 months of treatment. The nonfamilial alcoholic patients showed a slight response to fluoxetine; however, the mean number of alcoholic drinks significantly decreased (P < 0.05) during the homotaurinate treatment. In contrast, the familial alcoholic patients showed a significant decrease in ethanol intake (P < 0.05) after fluoxetine therapy and no effect after homotaurinate treatment. Our findings support the hypothesis that monoaminergic underactivity is present in familial alcoholic patients and suggest the possibility of specific chronic treatment of alcohol addiction related to preexisting personality disorders.
引用
收藏
页码:291 / 295
页数:5
相关论文
共 15 条
  • [1] AMPHETAMINE DERIVATIVES INDUCE LOCOMOTOR HYPERACTIVITY BY ACTING AS INDIRECT SEROTONIN AGONISTS
    CALLAWAY, CW
    JOHNSON, MP
    GOLD, LH
    NICHOLS, DE
    GEYER, MA
    [J]. PSYCHOPHARMACOLOGY, 1991, 104 (03) : 293 - 301
  • [2] COCORES JA, 1987, J CLIN PSYCHIAT, V48, P376
  • [3] GOODWIN D W, 1983, Substance and Alcohol Actions-Misuse, V4, P129
  • [4] GOODWIN DW, 1985, ARCH GEN PSYCHIAT, V42, P171
  • [5] THE NATURE OF ALCOHOLISM IN PATIENTS WITH DIFFERENT FAMILY HISTORIES FOR ALCOHOLISM
    HESSELBROCK, VM
    STABENAU, JR
    HESSELBROCK, MN
    MEYER, RE
    BABOR, TF
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1982, 6 (4-6) : 607 - 614
  • [6] KENT TA, 1985, LANCET, V18, P1005
  • [7] KHANTZIAN EJ, 1985, AM J PSYCHIAT, V142, P1259
  • [8] LUND C, 1979, CURRENT ALCOHOLISM, P325
  • [9] BEHAVIORAL EVIDENCE FOR THE INVOLVEMENT OF GAMMA-AMINOBUTYRIC ACID IN THE ACTIONS OF ETHANOL
    MARTZ, A
    DEITRICH, RA
    HARRIS, RA
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 89 (1-2) : 53 - 62
  • [10] NALPAS B, 1990, Encephale, V16, P175