SIMULTANEOUS LIVER AND LUNG TOXICITY RELATED TO THE NONSTEROIDAL ANTIANDROGEN NILUTAMIDE (ANANDRON) - A CASE-REPORT

被引：26

作者：

GOMEZ, JL

DUPONT, A

CUSAN, L

TREMBLAY, M

LABRIE, F

机构：

[1] CHU LAVAL, RES CTR,DEPT MOLEC ENDOCRINOL, ENDOCRINE CLIN RES UNIT,2705 LAURIER BLVD, QUEBEC CITY G1V 4G2, QUEBEC, CANADA

[2] CHU LAVAL, RES CTR, DEPT PATHOL, QUEBEC CITY G1V 4G2, QUEBEC, CANADA

[3] UNIV LAVAL, QUEBEC CITY G1K 7P4, QUEBEC, CANADA

来源：

AMERICAN JOURNAL OF MEDICINE | 1992年 / 92卷 / 05期

关键词：

D O I：

10.1016/0002-9343(92)90756-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 69-year-old patient treated for stage C adenocarcinoma of the prostate with the combination of the luteinizing hormone-releasing hormone agonist [D-Trp6, des-Gly-NH210] LHRH ethylamide and the antiandrogen nilutamide (Anandron) who developed simultaneous liver and lung toxicity. Investigation revealed an abnormal chest radiograph accompanied by altered respiratory function tests, suggesting the diagnosis of interstitial lung disease. This diagnosis was confirmed by an open chest biopsy. At the same time, liver function tests yielded abnormal results. All toxic manifestations disappeared after cessation of treatment with Anandron.

引用

页码：563 / 566

页数：4

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