CONFORMATIONAL-ANALYSIS OF AZITHROMYCIN BY NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY AND MOLECULAR MODELING

被引：38

作者：

LAZAREVSKI, G

VINKOVIC, M

KOBREHEL, G

DOKIC, S

METELKO, B

VIKICTOPIC, D

机构：

[1] RUDJER BOSKOVIC INST, 41000 ZAGREB, CROATIA

[2] NIDDK, ANALYT CHEM LAB, BETHESDA, MD 20892 USA

来源：

TETRAHEDRON | 1993年 / 49卷 / 03期

关键词：

AZITHROMYCIN; CONFORMATIONAL ANALYSIS; NMR SPECTROSCOPY; MOLECULAR MODELING;

D O I：

10.1016/S0040-4020(01)86274-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conformation of azithromycin 1 in the solution was determined by NMR spectroscopy and molecular mechanics calculations and compared with its crystal structure and with some erythromycin derivatives. In solution 1 exists predominantly in a ''folded-in '' conformation in the C-3 to C-5 region. whereas its crystal state conformation is ''folded-out''.

引用

页码：721 / 730

页数：10

共 18 条

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