BIOACTIVE DITERPENOIDS ISOLATED FROM DILOPHUS-LIGULATUS

被引：14

作者：

BOUAICHA, N

TRINGALI, C

PESANDO, D

MALLEA, M

ROUSSAKIS, C

VERBIST, JF

机构：

[1] UNIV NANTES,FAC PHARM,SMAB GRP RECH SUBST MARINES ACTIVITE BIOL,F-44035 NANTES,FRANCE

[2] UNIV CATANIA,DIPARTIMENTO SCI CHIM,I-95125 CATANIA,ITALY

来源：

PLANTA MEDICA | 1993年 / 59卷 / 03期

关键词：

DILOPHUS-LIGULATUS; DITERPENOIDS; ANTIFUNGAL ACTIVITY; CYTOTOXIC ACTIVITY; BROWN ALGAE;

D O I：

10.1055/s-2006-959663

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine diterpenoids, acetyldictyolal (1), epoxyoxodolabelladiene (2), dictyotalide B (3), neodictyolactone (4), pachylactone (5), the acetals 6a and 6b, isoacetoxycrenulatin (7), and dictyolactone (8) were isolated from the brown alga Dilophus ligulatus (Kutz.) Feldm. Their structures have been elucidated by comparison of mass, IR, H-1- and C-13-NMR spectra with reported literature data. Compounds 1, 2, 4, 7, and 8 exhibited antifungal activity. Cytotoxic activity against several types of mammalian cells (KB, P-388, P-388/DOX, and NSCLCN6-L16) in culture was examined for the 8 diterpenoids. Some of them showed stronger cytotoxicity than mercaptopurine which was used as a positive control in this study.

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页码：256 / 258

页数：3

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