INCREASED CEREBROSPINAL-FLUID CONCENTRATION OF NITRITE IN PARKINSONS-DISEASE

被引：112

作者：

OURESHI, GA

BAIG, S

BEDNAR, I

SODERSTEN, P

FORSBERG, G

SIDEN, A

机构：

[1] KAROLINSKA INST,HUDDINGE HOSP,NOVUM,CLIN RES CTR,S-14157 HUDDINGE,SWEDEN

[2] AGA KHAN UNIV,DEPT MED,KARACHI,PAKISTAN

来源：

NEUROREPORT | 1995年 / 6卷 / 12期

关键词：

ARGININE; NITRITE; NITRIC OXIDE; CEREBROSPINAL FLUID; PARKINSONS DISEASE;

D O I：

10.1097/00001756-199508000-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE concentration of nitrite, a metabolite of nitric oxide (NO), was increased in the cerebrospinal fluid (CSF) of untreated patients with Parkinson's disease and in patients treated with L-DOPA in comparison with a group of patients without dopaminergic dysfunction. There was no difference in the concentration of L-arginine (ARG), a precursor of NO, between the groups. There was a highly significant, linear relationship between the concentration of nitrite and ARG in the CSF suggesting that the production of NO is dependent on the availability of ARG. The results support the possibility thatproduction of NO is increased in the brain in Parkinson's disease.

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页码：1642 / 1644

页数：3

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